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Results Found: 4
  • Python Codebase for SeqC (SEquence Quality Control)

    Authors
    Carr, Ambrose James
    Choi, Kristy
    Pe'er, Dana
    Description

    SEQC is a python package that processes single-cell sequencing data in the cloud and analyzes it interactively on your local machine.

    Subject
    Sequence Analysis
    Access Rights
    Free to All
  • Histone H1 loss drives lymphoma by disrupting 3D chromatin architecture

    Authors
    Yusufova, Nevin
    Teater, Matt
    Cesarman, Ethel
    Melnick, Ari M.
    1 more author(s)...
    Description

    Summary from the GEO: "Linker histone H1 proteins bind to nucleosomes and cause chromatin compaction, although little is known about their biological functions. Histone H1 (HIST1H1B-E) mutations are highly recurrent in B-cell lymphomas and are present in solid tumors, but their cancer relevance and mechanism are unknown. Here we report that lymphoma-associated H1 alleles are genetic driver mutations...

    Subject
    B-Lymphocytes
    Gene Silencing
    Genes, Tumor Suppressor
    Histones
    Lymphoma
    Sequence Analysis
    Access Rights
    Free to All
  • Listeria seeligeri LS46 and LS59 Genome sequencing and assembly

    Description

    BioProject description: "Genome sequencing of Listeria seeligeri LS46 and LS59". The whole genome sequencing of these listeriaphage enabled researchers to discover that AcrVIA1, an anti-CRISPR protein, interacts with the guide-exposed face of Cas13a, a (crRNA)-guided nuclease, preventing access to the target RNA and the conformational changes required for nuclease activation. A single dose of AcrVIA1...

    Subject
    Listeria
    Sequence Analysis
    Whole Genome Sequencing
    Access Rights
    Free to All
  • R Script for the analysis of "Gastrointestinal microbiota composition predicts peripheral inflammatory state during treatment of human tuberculosis"

    Authors
    Bhattarai, Shakti
    Description

    R scripts used to for data analysis and figure support for the manuscript: Wipperman, M.F., Bhattarai, S.K., Vorkas, C.K. et al. Gastrointestinal microbiota composition predicts peripheral inflammatory state during treatment of human tuberculosis. Nat Commun 12, 1141 (2021). Data is available for download from Dropbox and the scripts listed are accessible from GitHub.

    Subject
    Sequence Analysis
    Access Rights
    Free to All